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Non-insulin pharmacological agents use different glucose-lowering mechanisms and can be used as monotherapy or in combination, while insulin provides the default medicine for the most advanced stages of this progressive disease [2,3,4]

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After the subcutaneous administration of GLP-1, it could enter the brain by binding to bloodbrainbarrier-free organs such as the subfornical organ and the area postrema [43], or through the choroid plexus, which has a high density of GLP-1 receptors [17]

Employers should be aware of this potential risk when designing coverage and utilization management policies